This work proposes automated solution for artifact and damage segmentation in biomedical images using machine learning algorithms. The development process includes data preprocessing, label classification using a clustering algorithm and segmentation model. CNN architectures like YOLO and U-NET are utilized for segmentation, and K-Means and DBSC algorithms are evaluated for clustering. The outcomes include a set of data preprocessing precodures, clustering algorithm testing and results analysis, segmentation model and recommendations for further development.